Non-specific phospholipase C (NPC): an emerging class of phospholipase C in plant growth and development

The Emerging Roles of Phospholipase C in Plant Growth and Development

In animals, the phospholipase Cs (PLCs) are recognized as key components of signaling, being involved in transducing messages delivered by hormones, neurotransmitters, and growth factors. Owing to their central role in animal biology, plant scientists have assumed an important role for these enzymes in plants. However, only recently we have begun to reveal the complexity with which PLCs can act...

Phosphoinositide-specific phospholipase C and mitogenic signaling.

The importance of PLC activation in cell proliferation is evident from the fact that the hydrolysis of PtdIns(4,5)P2 is one of the early events that follow the interaction of many growth factors and mitogens with their respective receptors. However, the importance of PLC activation is not restricted to proliferation; it is one of the most common transmembrane signaling events elicited by recept...

Regulation of phosphoinositide-specific phospholipase C.

The receptors involved in the regulation of phospholipase C by hormones, neurotransmitters and other ligands have seven transmembrane-spanning hydrophobic regions (seven-helix motif) and no known enzymatic activity. Furthermore these receptors can be isolated as complexes with guanine nucleotide binding (G) proteins. Guanine nucleotides affect the binding of hormones that stimulate phospholipas...

Supernatants From Human Osteosarcoma Cultured Cell Lines Induce Modifications in Growth and Differentiation of THP-1 Cells and Phosphoinositide- Specific Phospholipase C Enzymes

Introduction: Introduction: Molecular components within the microenvironment act upon cell growth, survival/apoptosis, and proliferation. Immune system cells respond to molecules produced by the tumor and released in the surrounding microenvironment, such as cytokines, chemokines, and growth factors. This study aimed to identify the effects of tumor environment on monocyte-macrophage cell linea...

HIP-70: an isoform of phosphoinositol-specific phospholipase C-alpha.